Safari Drive by Miller Hull Comments: There was a nice relationship between density and sustainability. The design of the dwelling spaces offers extraordinary options and there is a quality rare to multi-family projects. It appears that the architects developed an urban idea and promoted it throughout. Pedestrians have a deliberate place in the design and the work lends to a sense of community. Teddy works across the street and is supportive of the project. Novelty Hill Januik Winery by Mithun Comments: The program takes on a larger relationship between the building and surrounding wetlands.
There is a clear and intelligent experience throughout the spaces and the process of production is transparent. The blurred relationship between the interior and exterior is also pleasant.
The design accomplished an effective means of way-finding. The diagrams which accompanied the submittal were clever. Credits Giving proper credit for projects is important and AIA Seattle has done a very nice job documenting the teams for each of the projects above, you can check it out here. Summary comments from the jury: Most striking to the jury were the projects that are shaping the social and ecological environment.
The winning projects were very clear in their ideas. Most challenging to judge were the mid-size projects. They went back and forth several times and questioned their decisions all the way to the last minute. The jury was surprised that Northwest architects are struggling with the same things as architects elsewhere; they jokingly mentioned that they thought we might have the answers here in the northwest. Pharmaceutical companies have advanced drugs to clinical trials for rheumatoid arthritis and psoriasis based on Dong's work.
It was black and white, one or the other," Dong said. T cells are lymphocytes, a type of white blood cell produced by the thymus equipped with receptors that recognize and bind to antigens, pieces of invading organisms presented to the T cells by dendritic cells. The bound antigen converts the T cell to T helper cells that secrete signaling molecules called cytokines to launch an appropriate immune response.
Th1 mediates the immune response against microbial invaders such as viruses and bacteria, Dong said. Th2 coordinates attacks on large parasites that don't penetrate cells. Th1 was the prime suspect, Dong said, because it produces interferon-gamma IFN-y , a powerful cytokine associated with autoimmune and inflammatory diseases.
In , Dong and colleagues were busy characterizing molecules in addition to T cell receptors that control immune tolerance against self tissues, another field cited by the AAI award.
They exposed mice that were missing one of these crucial receptors from their T cells to a mouse model of rheumatoid arthritis. There was plenty of interferon gamma present in the mice, but no arthritis. There was no joint inflammation, antibody responses were reduced. It was remarkable," Dong said. His desire led to an intensive review of clinical research on autoimmune diseases, not the typical realm of a basic scientist. Some studies indicated IL was produced by a T cell of a type unknown.
Dong returned to his mutant mice and found minimal levels of IL Dong's subsequent major paper in Nature Immunology in November showed that ILproducing T cells are distinct from Th1 or Th2, and they could be generated in mice without any of the cytokines or transcription factors needed for the known T cell helpers.
They concluded that ILsecreting T cells are a new kind, the same conclusion reached independently by another group in Alabama in the same issue of the journal. The researchers at M. Anderson also showed that lungs become inflamed when IL is overexpressed in their inner lining. Blocking IL in a mouse model of multiple sclerosis greatly reduced the inflammation caused by that autoimmune disease. This influential paper helped jump-start a new era in T cell biology and has been cited by other scientists times.
Dong and colleagues have continued to publish on Th17 cells, now regarded as one of the hottest areas of biological research. Their paper in Nature elucidated IL, another cytokine produced by Th17 cells, in self-propagation of these cells. They also demonstrated the transcriptional regulation of Th17 development, function of Th17 cytokines, environmental regulation of Th17 function and the cell's significant plasticity.
Dong and two other scientists recently organized the first international Keystone Symposium on Th17 cells. Keystone Symposia gather top experts across disciplines to generate new ideas, exchange information and accelerate development of beneficial scientific applications.
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